Structure of PDB 3bsx Chain B Binding Site BS01

Receptor Information
>3bsx Chain B (length=340) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAE
RQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLS
LALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKC
IECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILE
ELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKF
ASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQK
MIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3bsx Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity.
Resolution2.32 Å
Binding residue
(original residue number in PDB)		Q867 N899 Y900 Q903 R936 Q939 H972 Q975 Y1005 R1008 Q1011 Y1041 N1043 Y1044 F1077 S1079 N1080 E1083 N1122 Y1123 Y1156 H1159
Binding residue
(residue number reindexed from 1)		Q40 N72 Y73 Q76 R109 Q112 H145 Q148 Y178 R181 Q184 Y214 N216 Y217 F250 S252 N253 E256 N295 Y296 Y329 H332
Binding affinityPDBbind-CN: Kd=2.8nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:3bsx, PDBe:3bsx, PDBj:3bsx
PDBsum3bsx
PubMed18328718
UniProtQ14671|PUM1_HUMAN Pumilio homolog 1 (Gene Name=PUM1)

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