Structure of PDB 3bsb Chain B Binding Site BS01

Receptor Information
>3bsb Chain B (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAE
RQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLS
LALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKC
IECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILE
ELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKF
ASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQK
MIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3bsb Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Q867 F897 N899 Y900 Y933 C935 R936 Q939 Q968 H972 Q975 R1008 Q1011 Y1041 N1043 Y1044 K1076 N1080 E1083 Y1120 N1122 Y1123 Q1126 Y1156 H1159
Binding residue
(residue number reindexed from 1)		Q40 F70 N72 Y73 Y106 C108 R109 Q112 Q141 H145 Q148 R181 Q184 Y214 N216 Y217 K249 N253 E256 Y293 N295 Y296 Q299 Y329 H332
Binding affinityPDBbind-CN: Kd=23.9nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:3bsb, PDBe:3bsb, PDBj:3bsb
PDBsum3bsb
PubMed18328718
UniProtQ14671|PUM1_HUMAN Pumilio homolog 1 (Gene Name=PUM1)

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