Structure of PDB 3b95 Chain B Binding Site BS01

Receptor Information
>3b95 Chain B (length=225) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVK
YLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGG
WTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAE
ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGE
TPLQCASLNSQVWSALQMSKALQDS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3b95 The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.
Resolution2.99 Å
Binding residue
(original residue number in PDB)		K817 K818 W843 W848 Y852 H854 E874 N876 W881 F884
Binding residue
(residue number reindexed from 1)		K75 K76 W101 W106 Y110 H112 E132 N134 W139 F142
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0002039 p53 binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3b95, PDBe:3b95, PDBj:3b95
PDBsum3b95
PubMed18264113
UniProtQ9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (Gene Name=EHMT1)

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