Structure of PDB 3b6p Chain B Binding Site BS01

Receptor Information
>3b6p Chain B (length=217) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPVP
RPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILL
RAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAA
LKALEQAKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALLQ
WVDEHARPFSTVKPMYG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3b6p Chain B Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3b6p Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D18 E20 D200
Binding residue
(residue number reindexed from 1)		D10 E12 D183
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3b6p, PDBe:3b6p, PDBj:3b6p
PDBsum3b6p
PubMed18780819
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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