Structure of PDB 3av9 Chain B Binding Site BS01

Receptor Information

>3av9 Chain B (length=150) Species: 11698 (Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE))

SSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLA
GRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEDGIPYNPQSQGVIESMN
KELKKIIGQVRDQAEHLKTAVQMAVFIHNHKRKGYSAGERIVDIIATDIQ

Ligand information

>3av9 Chain X (length=8) Species: 9606 (Homo sapiens)

SAKIDNLD

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3av9 Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): Q95 T124 T125
• Binding residue (residue number reindexed from 1): Q40 T69 T70

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:3av9, PDBe:3av9, PDBj:3av9
• PDBsum: 3av9
• PubMed: 21850718
• UniProt: P12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)