Structure of PDB 3a3k Chain B Binding Site BS01

Receptor Information
>3a3k Chain B (length=429) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVL
GSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHW
RVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQA
LVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLL
RAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKP
QKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFN
FTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRS
FQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSE
HKLYWPLGYPPPDVPKCGFDNEDPACNQD
Ligand information
Ligand IDBR
InChIInChI=1S/BrH/h1H/p-1
InChIKeyCPELXLSAUQHCOX-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Br-]
FormulaBr
NameBROMIDE ION
ChEMBL
DrugBank
ZINC
PDB chain3a3k Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3a3k Reversibly bound chloride in the atrial natriuretic peptide receptor hormone-binding domain: Possible allosteric regulation and a conserved structural motif for the chloride-binding site.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		P10 W18 S53 P84 C86
Binding residue
(residue number reindexed from 1)		P10 W18 S53 P84 C86
Annotation score1
Enzymatic activity
Enzyme Commision number 4.6.1.2: guanylate cyclase.
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:3a3k, PDBe:3a3k, PDBj:3a3k
PDBsum3a3k
PubMed20066666
UniProtP18910|ANPRA_RAT Atrial natriuretic peptide receptor 1 (Gene Name=Npr1)

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