Structure of PDB 2zzw Chain B Binding Site BS01

Receptor Information
>2zzw Chain B (length=330) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRYRWRIQTAWDAGTVGYSLFQKFTERVKELTDGQLEVQPFPAGAVVGTF
DMFDAVKTGVLDGMNPFTLYWAGRMPVTAFLSSYALGLDRPDQWETWFYS
LGGLDIARRAFAEQGLFYVGPVQHDLNIIHSKKPIRRFEDFKGVKLRVPG
GMIAEVFAAAGASTVLLPGGEVYPALERGVIDAADFVGPAVNYNLGFHQV
AKYIIMGPPETPAIHQPVDLMDFTINLNRWRSLPKPLQERFIAAVHEYSW
IHYAGIQKANLEAWPKYRQAGVEVIRLSNEDVRKFRRLAIPIWFKWAKMD
KYSREAFASQLEYMKGIGYVTDEELKGLSL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2zzw Chain B Residue 362 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2zzw Crystal structure of a periplasmic substrate-binding protein in complex with calcium lactate
Resolution1.95 Å
Binding residue
(original residue number in PDB)		N158 D216 F217 Q247
Binding residue
(residue number reindexed from 1)		N127 D185 F186 Q216
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0015727 lactate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0031317 tripartite ATP-independent periplasmic transporter complex

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Biological Process
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Cellular Component
External links
PDB RCSB:2zzw, PDBe:2zzw, PDBj:2zzw
PDBsum2zzw
PubMed19631222
UniProtQ5SK82|TLBP_THET8 Lactate-binding periplasmic protein TTHA0766 (Gene Name=TTHA0766)

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