Structure of PDB 2zc6 Chain B Binding Site BS01

Receptor Information
>2zc6 Chain B (length=384) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NYPAYMDNYLKEVINQVEEETGYNLLTTGMDVYTNVDQEAQKHLWDIYNT
DEYVAYPDDELQVASTIVDVSNGKVIAQLGARHQSSNVSFGINQAVETNR
DWGSTMKPITDYAPALEYGVYDSTATIVHDEPYNYPGTNTPVYNWDRGYF
GNITLQYALQQSRNVPAVETLNKVGLNRAKTFLNGLGIDYPSIHYSNAIS
SNTTESDKKYGASSEKMAAAYAAFANGGTYYKPMYIHKVVFSDGSEKEFS
NVGTRAMKETTAYMMTDMMKTVLSYGTGQNAYLAWLPQAGKTGTSNYTDE
EIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYSNRLTPLVGNGLTVAAK
VYRSMMTYLSEGSNPEDWNIPEGLYRNGEFVFKN
Ligand information
>2zc6 Chain A (length=16) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
TSSKIYDNKNQLIADL
Receptor-Ligand Complex Structure
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PDB2zc6 Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae
Resolution2.7 Å
Binding residue
(original residue number in PDB)		N267 P269 L291 L292 G295 M296 D297 V298 Y299 T300 V302 D303 Q304
Binding residue
(residue number reindexed from 1)		N1 P3 L25 L26 G29 M30 D31 V32 Y33 T34 V36 D37 Q38
Enzymatic activity
Enzyme Commision number 2.4.99.28: peptidoglycan glycosyltransferase.
3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Gene Ontology
Molecular Function
GO:0008658 penicillin binding

View graph for
Molecular Function
External links
PDB RCSB:2zc6, PDBe:2zc6, PDBj:2zc6
PDBsum2zc6
PubMed18391040
UniProtQ04707|PBPA_STRPN Penicillin-binding protein 1A (Gene Name=ponA)

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