Structure of PDB 2z3o Chain B Binding Site BS01

Receptor Information

>2z3o Chain B (length=231) Species: 562 (Escherichia coli)

RLVQLSRHSIAFPSPEGALREPNGLLALGGDLSPARLLMAYQRGIFPWFS
PGDPILWWSPDPRAVLWPESLHISRSMKRFHKRSPYRVTMNYAFGQVIEG
CASDREEGTWITRGVVEAYHRLHELGHAHSIEVWREDELVGGMYGVAQGT
LFCGESMFSRMENASKTALLVFCEEFIGHGGKLIDCQVLNDHTASLGACE
IPRRDYLNYLNQMRLGRLPNNFWVPRCLFSP

Ligand information

• Ligand ID: PHE
• InChI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
• InChIKey: COLNVLDHVKWLRT-QMMMGPOBSA-N
• SMILES:
  CACTVS 3.341: N[CH](Cc1ccccc1)C(O)=O
  CACTVS 3.341: N[C@@H](Cc1ccccc1)C(O)=O
  OpenEye OEToolkits 1.5.0: c1ccc(cc1)CC(C(=O)O)N
  OpenEye OEToolkits 1.5.0: c1ccc(cc1)C[C@@H](C(=O)O)N
  ACDLabs 10.04: O=C(O)C(N)Cc1ccccc1
• Formula: C9 H11 N O2
• Name: PHENYLALANINE
• ChEMBL: CHEMBL301523
• DrugBank: DB00120
• ZINC: ZINC000000105196
• PDB chain: 2z3o Chain B Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2z3o Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): G155 E156 S157 M158 L170 C187 Q188
• Binding residue (residue number reindexed from 1): G154 E155 S156 M157 L169 C186 Q187
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.3.2.6: lysine/arginine leucyltransferase.

Gene Ontology

Molecular Function

• GO:0008914 leucyl-tRNA--protein transferase activity
• GO:0016746 acyltransferase activity
• GO:0016755 aminoacyltransferase activity

Biological Process

• GO:0030163 protein catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2z3o, PDBe:2z3o, PDBj:2z3o
• PDBsum: 2z3o
• PubMed: 17891155
• UniProt: P0A8P1|LFTR_ECOLI Leucyl/phenylalanyl-tRNA--protein transferase (Gene Name=aat)