Structure of PDB 2yb8 Chain B Binding Site BS01

Receptor Information
>2yb8 Chain B (length=375) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDY
SVHRLILGTHTSDEQNHLLIASVQLPSGKIEIEIKINHEGEVNRARYMPQ
NACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW
NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW
HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS
EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS
SGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPN
EPWIICSVSEDNIMQVWQMAENVYN
Ligand information
>2yb8 Chain A (length=13) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NPIFLNRTLSYMK
Receptor-Ligand Complex Structure
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PDB2yb8 Histone Methylation by Prc2 is Inhibited by Active Chromatin Marks.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		E24 N31 F34 L35 D343 R345 Q358 D362 D365 G366 L370 G375 N411
Binding residue
(residue number reindexed from 1)		E9 N16 F19 L20 D304 R306 Q319 D323 D326 G327 L331 G336 N372
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0005515 protein binding
GO:0031491 nucleosome binding
GO:0042393 histone binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006335 DNA replication-dependent chromatin assembly
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0007307 eggshell chorion gene amplification
GO:0007346 regulation of mitotic cell cycle
GO:0007379 segment specification
GO:0031507 heterochromatin formation
GO:0034728 nucleosome organization
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:0140718 facultative heterochromatin formation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005700 polytene chromosome
GO:0016581 NuRD complex
GO:0016589 NURF complex
GO:0031523 Myb complex
GO:0033186 CAF-1 complex
GO:0035097 histone methyltransferase complex
GO:0035098 ESC/E(Z) complex
GO:0070822 Sin3-type complex
GO:0090575 RNA polymerase II transcription regulator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2yb8, PDBe:2yb8, PDBj:2yb8
PDBsum2yb8
PubMed21549310
UniProtQ24572|CAF1_DROME Chromatin assembly factor 1 p55 subunit (Gene Name=Caf1-55)

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