Structure of PDB 2xrf Chain B Binding Site BS01

Receptor Information
>2xrf Chain B (length=288) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RFVHVKNPYLDLMDEDILYHLDLGTKTHNLPAMFGDVKFVCVGGSPNRMK
AFALFMHKELGFEIKDICAGTDRYCMYKTGPVLAISHGMGIPSISIMLHE
LIKLLHHARCCDVTIIRIGTSGGIGIAPGTVVITDIAVDSFFKPRFEQVI
LDNIVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGRLD
GALCSFSREKKLDYLKRAFKAGVRNIEMESTVFAAMCGLCGLKAAVVCVT
LLDRLDCDQINLPHDVLVEYQQRPQLLISNFIRRRLGL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2xrf Chain B Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2xrf Crystal Structure of Human Uridine Phosphorylase 2
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D93 C95 T98 Y101
Binding residue
(residue number reindexed from 1)		D66 C68 T71 Y74
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E127 R281
Catalytic site (residue number reindexed from 1) E100 R254
Enzyme Commision number 2.4.2.3: uridine phosphorylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004850 uridine phosphorylase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0042802 identical protein binding
GO:0047847 deoxyuridine phosphorylase activity
Biological Process
GO:0006218 uridine catabolic process
GO:0006249 dCMP catabolic process
GO:0009116 nucleoside metabolic process
GO:0009164 nucleoside catabolic process
GO:0009166 nucleotide catabolic process
GO:0044206 UMP salvage
GO:0046108 uridine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0045098 type III intermediate filament

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xrf, PDBe:2xrf, PDBj:2xrf
PDBsum2xrf
PubMed
UniProtO95045|UPP2_HUMAN Uridine phosphorylase 2 (Gene Name=UPP2)

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