Structure of PDB 2xgj Chain B Binding Site BS01

Receptor Information
>2xgj Chain B (length=777) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HQVRHQVALPPNYDYTPIAEHKRVNEARTYPFTLDPFQDTAISCIDRGES
VLVSAHTSAGKTVVAEYAIAQSLKNKQRVIYTSPIKALSNQKYRELLAEF
GDVGLMTGDITINPDAGCLVMTTEILRSMLYRGSEVMREVAWVIFDEVHY
MRDKERGVVWEETIILLPDKVRYVFLSATIPNAMEFAEWICKIHSQPCHI
VYTNFRPTPLQHYLFPAHGDGIYLVVDEKSTFREENFQKAMASISKGDIY
KIVKMIWKKKYNPVIVFSFSKRDCEELALKMSKLDFNSDDEKEALTKIFN
NAIALLPETDRELPQIKHILPLLRRGIGIHHSGLLPILKEVIEILFQEGF
LKVLFATETFSIGPAKTVVFTSVVSGGEYIQMSGRAGRRGLDDRGIVIMM
IDEKMEPQVAKGMVKGQADRLDSAFHLGYNMILNLMRVEGISPEFMLEHS
FFQFQNVISVPVMEKKLAELKKDFDGIEVEDEENVKEYHEIEQAIKGYRE
DVRQVVTHPANALPVKNMKIEDEDFLKLMKKIDVLNTKLSSNPLTNSMRL
EELYGKYSRKHDLHEDMKQLKRKISESQAVIQLDDLRRRKRVLRRLGFCT
PNDIIELKGRVACEISSGDELLLTELIFNGNFNELKPEQAAALLSCFAFQ
ERCKEAPRLKPELAEPLKAMREIAAKIAKIMKDSKIEVVEKDYVESFRHE
LMEVVYEWCRGATFTQICKMTDVYEGSLIRMFKRLEELVKELVDVANTIG
NSSLKEKMEAVLKLIHRDIVSAGSLYL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2xgj Structural Analysis Reveals the Characteristic Features of Mtr4, a Dexh Helicase Involved in Nuclear RNA Processing and Surveillance.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		I201 K202 R272 F414 K416 H476 S477 T502 E947 R1026 R1030
Binding residue
(residue number reindexed from 1)		I85 K86 R156 F269 K271 H331 S332 T357 E651 R730 R734
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0003824 catalytic activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008143 poly(A) binding
GO:0016491 oxidoreductase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0034458 3'-5' RNA helicase activity
Biological Process
GO:0000292 RNA fragment catabolic process
GO:0000460 maturation of 5.8S rRNA
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0006401 RNA catabolic process
GO:0016075 rRNA catabolic process
GO:0034475 U4 snRNA 3'-end processing
GO:0034476 U5 snRNA 3'-end processing
GO:0071028 nuclear mRNA surveillance
GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0071038 TRAMP-dependent tRNA surveillance pathway
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process
GO:0071051 poly(A)-dependent snoRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0031499 TRAMP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xgj, PDBe:2xgj, PDBj:2xgj
PDBsum2xgj
PubMed20566885
UniProtP47047|MTR4_YEAST ATP-dependent RNA helicase DOB1 (Gene Name=MTR4)

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