Structure of PDB 2xcr Chain B Binding Site BS01

Receptor Information
>2xcr Chain B (length=718) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEK
ARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHI
RTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLK
SELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQ
TFEMLMGDVVENRRQFIEDNAVYANLDFAELPQSRINERNITSEMRESFL
DYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTPDKSYKKSARIVGD
VMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMRF
TEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGAS
GIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGL
ILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIVVTEIPFQVNKARM
IEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANASVILNNLYK
QTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRRTQYNLRK
AKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKLSEKQAQ
AILDMRLRRLTGLERDKIEAEYNELLNYISELETILADEEVLLQLVRDEL
TEIRDRFGDDRRTEIQLG
Ligand information
Receptor-Ligand Complex Structure
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PDB2xcr Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents.
Resolution3.5 Å
Binding residue
(original residue number in PDB)
E435 D437 S438 G459 K460 K581 R1033 V1045 H1046 H1079 H1081 R1092 R1272
Binding residue
(residue number reindexed from 1)
E19 D21 S22 G43 K44 K165 R260 V272 H273 H306 H308 R319 R499
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function

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Biological Process
External links
PDB RCSB:2xcr, PDBe:2xcr, PDBj:2xcr
PDBsum2xcr
PubMed20686482
UniProtP66937|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB);
Q99XG5|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)

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