Structure of PDB 2xbu Chain B Binding Site BS01

Receptor Information

>2xbu Chain B (length=202) Species: 4932 (Saccharomyces cerevisiae)

DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEP
GVPTIRIFAIILSLYEDLVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDT
RTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKA
DLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIP
EQ

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2xbu Chain B Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2xbu Functional Significance of Four Successive Glycine Residues in the Pyrophosphate Binding Loop of Fungal 6-Oxopurine Phosphoribosyltransferases.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): I36 G39 D110 E111
• Binding residue (residue number reindexed from 1): I32 G35 D95 E96
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.4.2.8: hypoxanthine phosphoribosyltransferase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004422 hypoxanthine phosphoribosyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0046872 metal ion binding
• GO:0052657 guanine phosphoribosyltransferase activity

Biological Process

• GO:0006166 purine ribonucleoside salvage
• GO:0009058 biosynthetic process
• GO:0032263 GMP salvage
• GO:0032264 IMP salvage
• GO:0032265 XMP salvage
• GO:0046100 hypoxanthine metabolic process

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:2xbu, PDBe:2xbu, PDBj:2xbu
• PDBsum: 2xbu
• PubMed: 22610485
• UniProt: Q04178|HPRT_YEAST Hypoxanthine-guanine phosphoribosyltransferase (Gene Name=HPT1)