Structure of PDB 2wv4 Chain B Binding Site BS01

Receptor Information

>2wv4 Chain B (length=196) Species: 12112 (Foot-and-mouth disease virus (strain A10-61))

TDLQKMVMGNTKPVELILDGKTVAICCATGVFGTAYLVPRHLFAEKYDKI
MLDGRAMTDSDYRVFEFEIKVKMLSDAALMVLHRGNKVRDITKHFRDTAR
MKKGTPVVGVVNNADVGRLIFSGEALTYKDIVVLMDGDTMPGLFAYKAAT
RAGYAGGAVLAADTFIVGTHSAGGNGVGYCSCVSRSMLQKMKAHVD

Ligand information

>2wv4 Chain D (length=9) Species: 12112 (Foot-and-mouth disease virus (strain A10-61))

APAKQLLNF

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2wv4 Insights Into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): T27 V28 A29 I30 C31 H46 L47 E50 L142 M143 D144 D146 T158 R159 A160 G161 A163 H181 A183 G184 Y190
• Binding residue (residue number reindexed from 1): T22 V23 A24 I25 C26 H41 L42 E45 L134 M135 D136 D138 T150 R151 A152 G153 A155 H170 A172 G173 Y179

Enzymatic activity

• Catalytic site (original residue number in PDB): H46 D84 A163 S182
• Catalytic site (residue number reindexed from 1): H41 D76 A155 S171
• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0004197 cysteine-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:2wv4, PDBe:2wv4, PDBj:2wv4
• PDBsum: 2wv4
• PubMed: 19883658
• UniProt: P03306|POLG_FMDV1 Genome polyprotein