Structure of PDB 2wnr Chain B Binding Site BS01

Receptor Information

>2wnr Chain B (length=222) Species: 145262 (Methanothermobacter thermautotrophicus)

SVREDGRAFDELRPLKIEAGILERADGSSYLEFGGNKILVAVYGPREAQI
RKLQRPDRAVIRCRYNMAPFSVEERKRPGPDRRSVEISKITAEALRPALI
LEKFPRSVIDVFIEVLEAEGGTRCAGITAASVALADAGIPMRDMVVACAA
GKVGDQVVLDLSEEEDKEGQADVPVAILPRTREITLLQSDGNLTPEEFER
ALDLAVEGCLRIHEVQKEALRK

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 2wnr Chain B Residue 1237

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2wnr Structure of the Methanothermobacter Thermautotrophicus Exosome Rnase Ph Ring
• Resolution: 2.65 Å
• Binding residue (original residue number in PDB): R97 G135 T136 R137
• Binding residue (residue number reindexed from 1): R83 G121 T122 R123
• Annotation score: 3

Enzymatic activity

• Enzyme Commision number: 3.1.13.-

Gene Ontology

Molecular Function

• GO:0000175 3'-5'-RNA exonuclease activity
• GO:0004527 exonuclease activity
• GO:0005515 protein binding
• GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters

Biological Process

• GO:0006401 RNA catabolic process
• GO:0016075 rRNA catabolic process

Cellular Component

• GO:0000177 cytoplasmic exosome (RNase complex)
• GO:0000178 exosome (RNase complex)
• GO:0005737 cytoplasm

External links

• PDB: RCSB:2wnr, PDBe:2wnr, PDBj:2wnr
• PDBsum: 2wnr
• PubMed: 20445227
• UniProt: O26779|RRP41_METTH Exosome complex component Rrp41 (Gene Name=rrp41)