Structure of PDB 2wja Chain B Binding Site BS01

Receptor Information

>2wja Chain B (length=138) Species: 562 (Escherichia coli)

MFDSILVICTGNICRSPIGERLLRRLLPSKKINSAGVGALVDHAADESAI
RVLCLKGHRGTKFTSALARQYDLLLVMEYSHLEQISRIAPEARGKTMLFG
HWLDSKEIPDPYRMSDEAFDSVYQLLEQASKRWAEKLG

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 2wja Chain B Residue 1148

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2wja Crystal Structures of Wzb of Escherichia Coli and Cpsb of Streptococcus Pneumoniae, Representatives of Two Families of Tyrosine Phosphatases that Regulate Capsule Assembly.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): C13 T14 G15 N16 C18 R19 D119
• Binding residue (residue number reindexed from 1): C9 T10 G11 N12 C14 R15 D110
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): C13 N16 C18 R19 S20 D119
• Catalytic site (residue number reindexed from 1): C9 N12 C14 R15 S16 D110
• Enzyme Commision number: 3.1.3.48: protein-tyrosine-phosphatase.

Gene Ontology

Molecular Function

• GO:0004721 phosphoprotein phosphatase activity
• GO:0004725 protein tyrosine phosphatase activity

Biological Process

• GO:0006470 protein dephosphorylation

External links

• PDB: RCSB:2wja, PDBe:2wja, PDBj:2wja
• PDBsum: 2wja
• PubMed: 19616007
• UniProt: Q9X4B8