Structure of PDB 2wfx Chain B Binding Site BS01

Receptor Information
>2wfx Chain B (length=417) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NCFCIQEVVSGLRQPVGALHSGDGSQRLFILEKEGYVKILTPEGEIFKEP
YLDIHKLVQSGIKDERGLLSLAFHPNYKKNGKLYVSYTTNDHILRVVEYT
VSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMIT
LDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTNQPPEVF
AHGLHDPGRCAVDRHPTDININLTILCSDSNRSSARILQIIKGKDYESEP
SLLEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTK
QWQEKPLCLHILGFGEDELGEVYILSSTHNGKLYKIVDPKRPLMPEECRA
TVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHG
GVCVRPNKCLCYLGPQC
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2wfx Chain A Residue 1192 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2wfx Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D383 C666
Binding residue
(residue number reindexed from 1)		D158 C417
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:2wfx, PDBe:2wfx, PDBj:2wfx
PDBsum2wfx
PubMed19561611
UniProtQ96QV1|HHIP_HUMAN Hedgehog-interacting protein (Gene Name=HHIP)

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