Structure of PDB 2wcu Chain B Binding Site BS01

Receptor Information
>2wcu Chain B (length=149) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVALKGIPKVLSPELLFALARMGHGDEIVLADANFPTSSICQCGPVEIRA
DGLDIPQLLEAVLRLLPLDTYVESPAAVMDLVPSDKEKGLQTPIWKRYES
LLLEADCKKTLMKLERFEFYERAKKAFAVVATGEMALYGNIILKKGTLD
Ligand information
Ligand IDFUC
InChIInChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1
InChIKeySHZGCJCMOBCMKK-SXUWKVJYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)C
OpenEye OEToolkits 1.5.0CC1C(C(C(C(O1)O)O)O)O
OpenEye OEToolkits 1.5.0C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O)O)O)O
CACTVS 3.341C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
FormulaC6 H12 O5
Namealpha-L-fucopyranose;
alpha-L-fucose;
6-deoxy-alpha-L-galactopyranose;
L-fucose;
fucose
ChEMBLCHEMBL1232862
DrugBankDB04473
ZINCZINC000001532814
PDB chain2wcu Chain B Residue 1150 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2wcu Crystal Structures and Enzyme Mechanism of a Dual Fucose Mutarotase/Ribose Pyranase
Resolution1.9 Å
Binding residue
(original residue number in PDB)		D32 N34 F35 M79 Y120 Y138 N140
Binding residue
(residue number reindexed from 1)		D32 N34 F35 M79 Y120 Y138 N140
Annotation score5
Enzymatic activity
Enzyme Commision number 5.1.3.29: L-fucose mutarotase.
Gene Ontology
Molecular Function
GO:0016853 isomerase activity
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives
GO:0036373 L-fucose mutarotase activity
GO:0042806 fucose binding
GO:0048029 monosaccharide binding
Biological Process
GO:0005996 monosaccharide metabolic process
GO:0006004 fucose metabolic process
GO:0030182 neuron differentiation
GO:0036065 fucosylation
GO:0045665 negative regulation of neuron differentiation
GO:0060180 female mating behavior
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wcu, PDBe:2wcu, PDBj:2wcu
PDBsum2wcu
PubMed19524593
UniProtQ8R2K1|FUCM_MOUSE Fucose mutarotase (Gene Name=Fuom)

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