Structure of PDB 2vya Chain B Binding Site BS01

Receptor Information
>2vya Chain B (length=541) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLV
QKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGL
LYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFV
HTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLG
LGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPM
ARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETD
NYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSD
GGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFL
NNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNT
PGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDI
ILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP
Ligand information
Ligand IDPF7
InChIInChI=1S/C16H18N2O2/c19-16(20)18-7-5-12(6-8-18)9-13-10-14-3-1-2-4-15(14)17-11-13/h1-4,10-12H,5-9H2,(H,19,20)
InChIKeyQUAGUFNCKDDJFZ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC(=O)N1CCC(CC1)Cc2cnc3ccccc3c2
ACDLabs 10.04O=C(O)N3CCC(Cc1cc2ccccc2nc1)CC3
OpenEye OEToolkits 1.5.0c1ccc2c(c1)cc(cn2)CC3CCN(CC3)C(=O)O
FormulaC16 H18 N2 O2
Name4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid
ChEMBL
DrugBankDB08385
ZINCZINC000038995984
PDB chain2vya Chain B Residue 1578 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2vya Structure-Guided Inhibitor Design for Human Faah by Interspecies Active Site Conversion.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		F192 S193 I238 G239 S241 F381 F432
Binding residue
(residue number reindexed from 1)		F159 S160 I205 G206 S208 F348 F399
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K142 S217 S218 T236 I238 G239 G240 S241 F244
Catalytic site (residue number reindexed from 1) K109 S184 S185 T203 I205 G206 G207 S208 F211
Enzyme Commision number 3.1.1.-
3.5.1.99: fatty acid amide hydrolase.
Gene Ontology
Molecular Function
GO:0004040 amidase activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017064 fatty acid amide hydrolase activity
GO:0042802 identical protein binding
GO:0047372 monoacylglycerol lipase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0009062 fatty acid catabolic process
GO:0016042 lipid catabolic process
GO:0045907 positive regulation of vasoconstriction
GO:0052651 monoacylglycerol catabolic process
GO:0150036 regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0031090 organelle membrane
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2vya, PDBe:2vya, PDBj:2vya
PDBsum2vya
PubMed18753625
UniProtP97612|FAAH1_RAT Fatty-acid amide hydrolase 1 (Gene Name=Faah)

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