Structure of PDB 2vrw Chain B Binding Site BS01

Receptor Information
>2vrw Chain B (length=367) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVN
IEELFSVHTHFLKELKDALAGPGATTLYQVFIKYKERFLVYGRYCSQVES
ASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLL
LQELVKHTQDATEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLS
IENLDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGD
SYDLKASVNLHSFQVRDKKWSHMFLLIEDQGAQGYELFFKTRELKKKWME
QFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCY
RCRAPAHKECLGRVPPC
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2vrw Chain B Residue 1565 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2vrw Crucial Structural Role for the Ph and C1 Domains of the Vav1 Exchange Factor.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		H516 C546 C549 C564
Binding residue
(residue number reindexed from 1)		H319 C349 C352 C367
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:2vrw, PDBe:2vrw, PDBj:2vrw
PDBsum2vrw
PubMed18511940
UniProtP27870|VAV_MOUSE Proto-oncogene vav (Gene Name=Vav1)

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