Structure of PDB 2va2 Chain B Binding Site BS01

Receptor Information

>2va2 Chain B (length=343) Species: 273057 (Saccharolobus solfataricus P2)

HMIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYE
ARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKI
EIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKV
FAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGI
NKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIV
TMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRG
RTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFIE

Ligand information

>2va2 Chain E (length=13)

gggggaaggacta

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2va2 Structure and Activity of Y-Class DNA Polymerase Dpo4 from Sulfolobus Solfataricus with Templates Containing the Hydrophobic Thymine Analog 2,4- Difluorotoluene.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): S103 D105 E106 K152 G185 G187 I189 T190 S297 R298 T301 K339
• Binding residue (residue number reindexed from 1): S104 D106 E107 K153 G186 G188 I190 T191 S298 R299 T302 K340

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003677 DNA binding
• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006281 DNA repair
• GO:0006974 DNA damage response
• GO:0042276 error-prone translesion synthesis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2va2, PDBe:2va2, PDBj:2va2
• PDBsum: 2va2
• PubMed: 17951245
• UniProt: Q97W02|DPO4_SACS2 DNA polymerase IV (Gene Name=dbh)