Structure of PDB 2v27 Chain B Binding Site BS01

Receptor Information
>2v27 Chain B (length=272) Species: 167879 (Colwellia psychrerythraea 34H) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTKYVSKVPDEHGFIEWSTEENLIWQELFTRQIACIKDKACDEYHEGLAK
LNLPTDRIPQLDEVSKVLKVSTGWECYPVPALIGFGEFFRLLSEKKFPVA
TFIRSREEMDYLQEPDIFHEIFGHCPLLTNSSFANYTEAYGKMGLNATKE
QRVFLARLYWFTIEFGLLDTPKGLRIYGGGVLSSPGETDYAMNNTDVDRK
PFDILDVLRTPYRIDIMQPIYYMLTKVSDLDEIRKFEVDDIMELVAQAEA
LGLHEAKFPVKKASLEHHHHHH
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain2v27 Chain B Residue 3008 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2v27 Structure of Phenylalanine Hydroxylase from Colwellia Psychrerythraea 34H, a Monomeric Cold Active Enzyme with Local Flexibility Around the Active Site and High Overall Stability.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		H122 H127 E167
Binding residue
(residue number reindexed from 1)		H119 H124 E164
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H122 H127 E167 S186
Catalytic site (residue number reindexed from 1) H119 H124 E164 S183
Enzyme Commision number 1.14.16.1: phenylalanine 4-monooxygenase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004505 phenylalanine 4-monooxygenase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0046872 metal ion binding
Biological Process
GO:0006559 L-phenylalanine catabolic process
GO:0009072 aromatic amino acid metabolic process
GO:0019293 tyrosine biosynthetic process, by oxidation of phenylalanine

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2v27, PDBe:2v27, PDBj:2v27
PDBsum2v27
PubMed17537732
UniProtQ47XN7

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