Structure of PDB 2uu7 Chain B Binding Site BS01

Receptor Information
>2uu7 Chain B (length=370) Species: 9615 (Canis lupus familiaris) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPK
GVEELPEWNFDGSSTFQSEGSNSDMYLVPAAMFRDPFRKDPNKLVFCEVF
KYNRKPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSN
GFPGPQGPYYCGVGADKAYGRDIVEAHYRACLYAGIKIAGTNAEVMPAQW
EFQIGPCEGIDMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGC
HTNFSTKAMREENGLKYIEESIEKLSKRHQYHIRAYDPKGGLDNARRLTG
FHETSNINDFSAGVANRGASIRIPRTVGQEKKGYFEDRRPSANCDPFSVT
EALIRTCLLNETGDEPFQYK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2uu7 Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2uu7 Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E136 E196 E203
Binding residue
(residue number reindexed from 1)		E134 E194 E201
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.225: protein S-acyltransferase.
6.3.1.2: glutamine synthetase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004356 glutamine synthetase activity
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016874 ligase activity
GO:0019706 protein-cysteine S-palmitoyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0006542 glutamine biosynthetic process
GO:0010594 regulation of endothelial cell migration
GO:0018345 protein palmitoylation
GO:1903670 regulation of sprouting angiogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2uu7, PDBe:2uu7, PDBj:2uu7
PDBsum2uu7
PubMed18005987
UniProtQ8HZM5|GLNA_CANLF Glutamine synthetase (Gene Name=GLUL)

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