Structure of PDB 2rfd Chain B Binding Site BS01

Receptor Information
>2rfd Chain B (length=286) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKAN
KEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHK
DNIGSQYLLNWCVQIAEGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDF
GLAKLLGAEGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP
YDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFREL
IIEFSKMARDPQRYLVIQGDERMHLPDVVDADEYLI
Ligand information
Receptor-Ligand Complex Structure
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PDB2rfd Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		E904 G906 E907 R908 P910 Q911 Y920 V924 M928 I929
Binding residue
(residue number reindexed from 1)		E214 G216 E217 R218 P220 Q221 Y230 V234 M238 I239
Enzymatic activity
Catalytic site (original residue number in PDB) D813 A815 R817 N818 D831 G850
Catalytic site (residue number reindexed from 1) D131 A133 R135 N136 D149 G160
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2rfd, PDBe:2rfd, PDBj:2rfd
PDBsum2rfd
PubMed18046415
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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