Structure of PDB 2rcb Chain B Binding Site BS01

Receptor Information
>2rcb Chain B (length=282) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAAL
VNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRDGRW
TGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRGTE
LSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTP
HGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIG
LPQNSPLTSNLSEFISRYKSSGFIDLLHDKWY
Ligand information
Ligand IDDSN
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
InChIKeyMTCFGRXMJLQNBG-UWTATZPHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C([C@H](C(=O)O)N)O
CACTVS 3.341N[C@H](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
ACDLabs 10.04O=C(O)C(N)CO
FormulaC3 H7 N O3
NameD-SERINE
ChEMBLCHEMBL285123
DrugBankDB03929
ZINCZINC000000895342
PDB chain2rcb Chain B Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2rcb Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.
Resolution1.62 Å
Binding residue
(original residue number in PDB)		Y95 S121 S123 R128 S177 S178 M221 D222
Binding residue
(residue number reindexed from 1)		Y92 S118 S120 R125 S174 S175 M218 D219
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:2rcb, PDBe:2rcb, PDBj:2rcb
PDBsum2rcb
PubMed18636091
UniProtQ8VHN2|NMD3B_RAT Glutamate receptor ionotropic, NMDA 3B (Gene Name=Grin3b)

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