Structure of PDB 2r9b Chain B Binding Site BS01

Receptor Information
>2r9b Chain B (length=329) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTA
GCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPY
KFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIE
NALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAH
VGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCN
NSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFI
LGDPFMRKYFTVFDYDNHSVGIALAKKNL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2r9b Recombinant plasmepsin 1 from the human malaria parasite plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		I32 D34 G36 S37 A38 M75 N76 Y77 V78 S79 I123 L131 Y192 G216 T217 S218 I290
Binding residue
(residue number reindexed from 1)		I32 D34 G36 S37 A38 M75 N76 Y77 V78 S79 I123 L131 Y192 G216 T217 S218 I290
Enzymatic activity
Enzyme Commision number 3.4.23.39: plasmepsin II.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2r9b, PDBe:2r9b, PDBj:2r9b
PDBsum2r9b
PubMed19271776
UniProtP46925|PLM2_PLAFX Plasmepsin II (Gene Name=PMII)

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