Structure of PDB 2qt6 Chain B Binding Site BS01

Receptor Information

>2qt6 Chain B (length=498) Species: 5365 (Lentinus tigrinus)

AVGPVADLTVTNANIVPDGFERAAIVVNNVFPAPLITGNMGDNFQLNLVN
QMTNHTMLKTTSIHWHGFFQKGTNWADGPAFINQCPIASGNSFLYDFQVP
GQAGTFWYHSHLSTQYCDGLRGPFVVYDPNDPHANLYDVDDESTVITLAD
WYHVAAKLGPRFPKGADSTLINGLGRSTSTPTADLAVISVTKGKRYRFRL
VSLSCDPNYTFSIDSHQLTVIEADGVSTQPVTVDSIQIFAAQRYSFVLNA
NQDVDNYWIRANPNFGTTGFADGVNSAILRYDDADPVEPVTNQTGTTLLL
ETDLHPLTSMPVPGNPTQGGADLNLNMAFNFDGTNFFINGESFTPPTVPV
LLQIISGANTAQDLLPSGSVYSLPSNSSIEITFPATTAAPGAPHPFHLHG
HVFAVVRSAGSTSYNYDDPVWRDVVSTGTPQAGDNVTIRFQTDNPGPWFL
HCHIDFHLDAGFAVVMAEDIPNTVNANPVPQAWSNLCPTYDALEPSNE

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 2qt6 Chain B Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2qt6 Crystal structure of a blue laccase from Lentinus tigrinus: evidences for intermediates in the molecular oxygen reductive splitting by multicopper oxidases.
• Resolution: 1.5 Å
• Binding residue (original residue number in PDB): H394 C452 H457
• Binding residue (residue number reindexed from 1): H394 C452 H457
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H64 H66 H109 H111 H394 H397 H399 H451 C452 H453 I454 H457 F462
• Catalytic site (residue number reindexed from 1): H64 H66 H109 H111 H394 H397 H399 H451 C452 H453 I454 H457 F462
• Enzyme Commision number: 1.10.3.2: laccase.

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0052716 hydroquinone:oxygen oxidoreductase activity

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:2qt6, PDBe:2qt6, PDBj:2qt6
• PDBsum: 2qt6
• PubMed: 17897461
• UniProt: Q5EBY5