Structure of PDB 2qqs Chain B Binding Site BS01
Receptor Information
>2qqs Chain B (length=108) Species:
9606
(Homo sapiens) [
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ITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVS
QDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVV
KRDDVYTL
Ligand information
>2qqs Chain C (length=5) Species:
9606
(Homo sapiens) [
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RHRKV
Receptor-Ligand Complex Structure
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PDB
2qqs
Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor.
Resolution
2.82 Å
Binding residue
(original residue number in PDB)
N931 G935 S936 F937 D939 W967
Binding residue
(residue number reindexed from 1)
N33 G37 S38 F39 D41 W69
Enzymatic activity
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:2qqs
,
PDBe:2qqs
,
PDBj:2qqs
PDBsum
2qqs
PubMed
18084306
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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