Structure of PDB 2qfi Chain B Binding Site BS01

Receptor Information
>2qfi Chain B (length=286) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YGRLVSRAAIAATAMASLLLLIKIFAWWYTGSVSILAALVDSLVDIGASL
TNLLVVRYSLQPADDNHSFGHGKAESLAALAQSMFISGSALFLFLTGIQH
LISPTPMTDPGVGVIVTIVALICTIILVSFQRWVVRRTQSQAVRADMLHY
QSDVMMNGAILLALGLSWYGWHRADALFALGIGIYILYSALRMGYEAVQS
LLDRALPDEERQEIIDIVTSWPGVSGAHDLRTRQSGPTRFIQIHLEMEDS
LPLVQAHMVADQVEQAILRRFPGSDVIIHQDPCSVV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2qfi Chain B Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2qfi Structure of the zinc transporter YiiP.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		H283 D285
Binding residue
(residue number reindexed from 1)		H279 D281
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005381 iron ion transmembrane transporter activity
GO:0005385 zinc ion transmembrane transporter activity
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015093 ferrous iron transmembrane transporter activity
GO:0015297 antiporter activity
GO:0015341 zinc efflux active transmembrane transporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0046873 metal ion transmembrane transporter activity
GO:0140826 zinc:proton antiporter activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0006826 iron ion transport
GO:0006829 zinc ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0006882 intracellular zinc ion homeostasis
GO:0034755 iron ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070574 cadmium ion transmembrane transport
GO:0071577 zinc ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2qfi, PDBe:2qfi, PDBj:2qfi
PDBsum2qfi
PubMed17717154
UniProtP69380|FIEF_ECOLI Cation-efflux pump FieF (Gene Name=fieF)

[Back to BioLiP]