Structure of PDB 2qb6 Chain B Binding Site BS01

Receptor Information

>2qb6 Chain B (length=388) Species: 4932 (Saccharomyces cerevisiae)

LRKTVPEFLAHLKSLPISKIASNDVLTICVGNESADMDSIASAITYSYCQ
YIYNEGTYSEEKKKGSFIVPIIDIPREDLSLRRDVMYVLEKLKIKEEELF
FIEDLKSLKQNVSQGTELNSYLVDNNDTPKNLKNYIDNVVGIIDHHFDLQ
KHLDAEPRIVKVSGSCSSLVFNYWYEKLQGDREVVMNIAPLLMGAILIDT
SNMRRKVEESDKLAIERCQAVLSGAVNEVSAQGLEDSSEFYKEIKSRKND
IKGFSVSDILKKDYKQFNFGLEIGLSSIVKRMSWLFNEHGGEADFVNQCR
RFQAERGLDVLVLLTSWRKAGDSHRELVILGDSNVVRELIERVSDKLQLQ
LFGGNLDGGVAMFKQLNVEATRKQVVPYLEEAYSNLEE

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 2qb6 Chain B Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2qb6 The crystal structure of the cytosolic exopolyphosphatase from Saccharomyces cerevisiae reveals the basis for substrate specificity.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): D41 D127 H148
• Binding residue (residue number reindexed from 1): D38 D124 H145
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.1.11: exopolyphosphatase.

Gene Ontology

Molecular Function

• GO:0004309 exopolyphosphatase activity
• GO:0005524 ATP binding
• GO:0016462 pyrophosphatase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006798 polyphosphate catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2qb6, PDBe:2qb6, PDBj:2qb6
• PDBsum: 2qb6
• PubMed: 17599355
• UniProt: P38698|PPX1_YEAST Polyphosphatase (Gene Name=PPX1)