Structure of PDB 2q8c Chain B Binding Site BS01
Receptor Information
>2q8c Chain B (length=335) Species:
9606
(Homo sapiens) [
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ARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDD
IDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRY
SEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVE
KESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSV
PPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVT
QEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKD
MVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLP
Ligand information
>2q8c Chain G (length=8) [
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TARKSTGG
Receptor-Ligand Complex Structure
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PDB
2q8c
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Resolution
2.047 Å
Binding residue
(original residue number in PDB)
N86 D135 E169 G170 Y175 Y177 H240 K241 M242 S288 T289 N290 V313
Binding residue
(residue number reindexed from 1)
N75 D124 E158 G159 Y164 Y166 H229 K230 M231 S277 T278 N279 V302
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G159 Y166 H177 E179 H265 S277
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:2q8c
,
PDBe:2q8c
,
PDBj:2q8c
PDBsum
2q8c
PubMed
17589523
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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