Structure of PDB 2q6g Chain B Binding Site BS01

Receptor Information

>2q6g Chain B (length=302) Species: 228407 (SARS coronavirus BJ01)

SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRAVICTAEDML
NPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPK
YKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGF
NIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTI
TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL
GPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC
SG

Ligand information

>2q6g Chain D (length=8) Species: 694009 (Severe acute respiratory syndrome-related coronavirus)

TSAVLQSG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2q6g Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): T25 T26 M49 L141 N142 G143 C145 H163 H164 M165 E166 D187 Q189 T190
• Binding residue (residue number reindexed from 1): T25 T26 M49 L141 N142 G143 C145 H163 H164 M165 E166 D187 Q189 T190

Enzymatic activity

• Catalytic site (original residue number in PDB): A41 G143 C145
• Catalytic site (residue number reindexed from 1): A41 G143 C145
• Enzyme Commision number: 2.1.1.-
  2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.50: mRNA guanylyltransferase.
  3.1.13.-
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.4.22.-
  3.4.22.69: SARS coronavirus main proteinase.
  3.6.4.12: DNA helicase.
  3.6.4.13: RNA helicase.
  4.6.1.-

Gene Ontology

Molecular Function

• GO:0008233 peptidase activity

Biological Process

• GO:0019082 viral protein processing

External links

• PDB: RCSB:2q6g, PDBe:2q6g, PDBj:2q6g
• PDBsum: 2q6g
• PubMed: 18094151
• UniProt: P0C6X7|R1AB_SARS Replicase polyprotein 1ab (Gene Name=rep)