Structure of PDB 2q5d Chain B Binding Site BS01

Receptor Information
>2q5d Chain B (length=845) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNS
QVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLG
TETYRPSSASQCVAGIACAEIPVNQWPELIPQLVANVTNPNSTEHMKEST
LEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLN
SLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQ
YMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGV
CLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPS
QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLA
PLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLS
SSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKT
TLVIMERLQQVLQMSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVV
MASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIG
QVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQIL
SVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVYLNELRESCLEAYTGIV
QGQPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGK
DVLKLVEARPMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
Ligand information
>2q5d Chain D (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ERRRRLLELQKSKRLDYVNHARR
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2q5d Molecular Basis for the Recognition of Snurportin 1 by Importin {beta}.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R679 L722
Binding residue
(residue number reindexed from 1)		R665 L708
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0031267 small GTPase binding
GO:0051879 Hsp90 protein binding
GO:0061608 nuclear import signal receptor activity
GO:0061676 importin-alpha family protein binding
Biological Process
GO:0006404 RNA import into nucleus
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0006610 ribosomal protein import into nucleus
GO:0006886 intracellular protein transport
GO:0007079 mitotic chromosome movement towards spindle pole
GO:0007080 mitotic metaphase chromosome alignment
GO:0015031 protein transport
GO:0030953 astral microtubule organization
GO:0040001 establishment of mitotic spindle localization
GO:0090307 mitotic spindle assembly
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0032991 protein-containing complex
GO:0035580 specific granule lumen
GO:0042564 NLS-dependent protein nuclear import complex
GO:0070062 extracellular exosome
GO:0071782 endoplasmic reticulum tubular network
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2q5d, PDBe:2q5d, PDBj:2q5d
PDBsum2q5d
PubMed18187419
UniProtQ14974|IMB1_HUMAN Importin subunit beta-1 (Gene Name=KPNB1)

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