Structure of PDB 2pvs Chain B Binding Site BS01

Receptor Information
>2pvs Chain B (length=445) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVCYGQLGCFSDEKPWAGTLQRPVKLLPWSPEDIDTRFLLYTNENPNNF
QLITGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPSDMCKKMFEVEK
VNCICVDWRHGSRAMYTQAVQNIRVVGAETAFLIQALSTQLGYSLEDVHV
IGHSLGAHTAAEAGRRLGGRVGRITGLDPAGPCFQDEPEEVRLDPSDAVF
VDVIHTDSSPIVPSLGFGMSQKVGHLDFFPNGGKEMPGCKKNIDGIWEGI
GGFVSCNHLRSFEYYSSSVLNPDGFLGYPCASYDEFQESKCFPCPAEGCP
KMGHYADQFKGKTSAVEQTFFLNTGESGQFTSWRYKVSVTLSGKEKVNGY
IRIALYGSNENSKQYEIFKGSLKPDASHTCAIDVDFNVGKIQKVKFLWNK
RGINLSEPKLGASQITVQSGEDGTEYNFCSSDTVEENVLQSLYPC
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2pvs Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2pvs Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E187 R190 D192 D195
Binding residue
(residue number reindexed from 1)		E189 R192 D194 D197
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) F77 S152 L153 D176 H263
Catalytic site (residue number reindexed from 1) F79 S154 L155 D178 H258
Enzyme Commision number 3.1.1.26: galactolipase.
3.1.1.3: triacylglycerol lipase.
Gene Ontology
Molecular Function
GO:0004620 phospholipase activity
GO:0004806 triacylglycerol lipase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016298 lipase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047372 monoacylglycerol lipase activity
GO:0047714 galactolipase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0009395 phospholipid catabolic process
GO:0016042 lipid catabolic process
GO:0019376 galactolipid catabolic process
GO:0019433 triglyceride catabolic process
GO:0034638 phosphatidylcholine catabolic process
GO:0044241 lipid digestion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0042589 zymogen granule membrane
GO:0042995 cell projection
GO:0043005 neuron projection

View graph for
Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:2pvs, PDBe:2pvs, PDBj:2pvs
PDBsum2pvs
PubMed18702514
UniProtP54317|LIPR2_HUMAN Pancreatic lipase-related protein 2 (Gene Name=PNLIPRP2)

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