Structure of PDB 2pjb Chain B Binding Site BS01

Receptor Information

>2pjb Chain B (length=305) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TGHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGK
PGPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLD
FYVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTT
GASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMIL
YPYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGG
SDDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNY
VLGHL

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

2pjb Chain B Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	2pjb Structures of potent selective peptide mimetics bound to carboxypeptidase B.
Resolution	1.7 Å
Binding residue (original residue number in PDB)	H69 E72 H196
Binding residue (residue number reindexed from 1)	H65 E68 H193
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1)	H65 E68 R123 H193 E267
Enzyme Commision number	3.4.17.2: carboxypeptidase B.

Gene Ontology

	Molecular Function
GO:0004181	metallocarboxypeptidase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2pjb, PDBe:2pjb, PDBj:2pjb
PDBsum	2pjb
PubMed	18219114
UniProt	P09955\|CBPB1_PIG Carboxypeptidase B (Gene Name=CPB1)

[Back to BioLiP]