Structure of PDB 2p5o Chain B Binding Site BS01

Receptor Information
>2p5o Chain B (length=771) Species: 12353 (Escherichia phage RB69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYF
DIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYE
IKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFD
LLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLME
YLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRV
KVIENMEIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNVGKLK
YDGPISKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYYAKIQ
IQSVFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPIPNRY
KYVMSFDLTSLYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERPSDVY
SCSPNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNMLFRAQRTE
VAGMTAQINRKLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQWIER
KVNEYLNEVCGTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHWVD
FLDKFARERMEPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKGIG
GFWTGKKRYALNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKECI
RRMLQEGEESLQEYFKEFEKEFRQLNYISIDVLHWMDYTVLLEKTFIKPL
EGFTSAAKLDYEKKASLFDMF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2p5o Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E116 V117 G122 F123 N217 F221 S287 Y288 S289 L290 S735
Binding residue
(residue number reindexed from 1)		E116 V117 G122 F123 N217 F221 S283 Y284 S285 L286 S686
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2p5o, PDBe:2p5o, PDBj:2p5o
PDBsum2p5o
PubMed15057283
UniProtQ38087|DPOL_BPR69 DNA-directed DNA polymerase (Gene Name=43)

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