Structure of PDB 2oxe Chain B Binding Site BS01

Receptor Information
>2oxe Chain B (length=431) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVCYGQLGCFSDEKPWAGTLQRPVKLLPWSPEDIDTRFLLYTNENPNNF
QLITGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPSDMCKKMFEVEK
VNCICVDWRHGSRAMYTQAVQNIRVVGAETAFLIQALSTQLGYSLEDVHV
IGHSLGAHTAAEAGRRLGGRVGRITGLDPAGPCFQDEPEEVRLDPSDAVF
VDVIHTDSSPIVPSLGFGMSQKVGHLDFFPNGGKEMPGCGIGGFVSCNHL
RSFEYYSSSVLNPDGFLGYPCASYDEFQESKCFPCPAEGCPKMGHYADQF
KGKTSAVEQTFFLNTGESGNFTSWRYKVSVTLSGKEKVNGYIRIALYGSN
ENSKQYEIFKGSLKPDASHTCAIDVDFNVGKIQKVKFLWNKSEPKLGASQ
ITVQSGEDGTEYNFCSSDTVEENVLQSLYPC
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain2oxe Chain D Residue 4 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2oxe Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		N383 N385
Binding residue
(residue number reindexed from 1)		N350 N352
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) F96 S171 L172 D195 H282
Catalytic site (residue number reindexed from 1) F79 S154 L155 D178 H249
Enzyme Commision number 3.1.1.26: galactolipase.
3.1.1.3: triacylglycerol lipase.
Gene Ontology
Molecular Function
GO:0004620 phospholipase activity
GO:0004806 triacylglycerol lipase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016298 lipase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047372 monoacylglycerol lipase activity
GO:0047714 galactolipase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0009395 phospholipid catabolic process
GO:0016042 lipid catabolic process
GO:0019376 galactolipid catabolic process
GO:0019433 triglyceride catabolic process
GO:0034638 phosphatidylcholine catabolic process
GO:0044241 lipid digestion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0042589 zymogen granule membrane
GO:0042995 cell projection
GO:0043005 neuron projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2oxe, PDBe:2oxe, PDBj:2oxe
PDBsum2oxe
PubMed18702514
UniProtP54317|LIPR2_HUMAN Pancreatic lipase-related protein 2 (Gene Name=PNLIPRP2)

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