Structure of PDB 2ox0 Chain B Binding Site BS01
Receptor Information
>2ox0 Chain B (length=348) Species:
9606
(Homo sapiens) [
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TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPR
ASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKY
CTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTI
LDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPK
SWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIP
FDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLC
SCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL
Ligand information
>2ox0 Chain D (length=8) Species:
9606
(Homo sapiens) [
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ARKSTGGK
Receptor-Ligand Complex Structure
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PDB
2ox0
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Resolution
1.95 Å
Binding residue
(original residue number in PDB)
Y85 N86 I87 Q88 D135 I168 E169 G170 Y175 Y177 H240 K241 M242 S288 T289 N290 D311 V313
Binding residue
(residue number reindexed from 1)
Y79 N80 I81 Q82 D129 I162 E163 G164 Y169 Y171 H234 K235 M236 S282 T283 N284 D305 V307
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G164 Y171 H182 E184 H270 S282
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:2ox0
,
PDBe:2ox0
,
PDBj:2ox0
PDBsum
2ox0
PubMed
17589501
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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