Structure of PDB 2oa8 Chain B Binding Site BS01

Receptor Information
>2oa8 Chain B (length=226) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QTLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGH
PPPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDN
LAILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCV
DSIAALKALEQASRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQW
KPQALLQWVDEHARPFSTVKPMYGTA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2oa8 The Crystal Structure of TREX1 Explains the 3' Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		E20 A21 G23 L24 G80 A81 H124 N125 Y129 I156 S176 Y177 S178 L179
Binding residue
(residue number reindexed from 1)		E17 A18 G20 L21 G77 A78 H121 N122 Y126 I153 S166 Y167 S168 L169
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2oa8, PDBe:2oa8, PDBj:2oa8
PDBsum2oa8
PubMed17293595
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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