Structure of PDB 2o8e Chain B Binding Site BS01

Receptor Information
>2o8e Chain B (length=935) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMR
KWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGF
PEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRR
EICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEDSSHTRAYGVCFVD
TSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSS
LSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIVMLPQVLKGMT
SESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLD
SDTVSKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKR
LLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLL
SKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKII
GIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKAR
KTGLITPKAGFSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIG
RNRYQLEIPENFTTRNLPEYELKSTKKGCKRYWTKTIEKKLANLINAEER
RDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPM
CRPVILLPEDTPPFLELKGSRHPCITFGDDFIPNDILIGCEEEEQEGKAY
CVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLG
STFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAE
TIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMTFLYKFIKGACPKSYGF
NAARLANLPEEVIQKGHRKAREFEKMNQSLRLFRE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2o8e Structure of the Human MutSalpha DNA Lesion Recognition Complex.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		T407 G409 M410 V429 G430 K431 F432 P489 V508 V509 R511 Y845
Binding residue
(residue number reindexed from 1)		T46 G48 M49 V68 G69 K70 F71 P128 V147 V148 R150 Y473
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2o8e, PDBe:2o8e, PDBj:2o8e
PDBsum2o8e
PubMed17531815
UniProtP52701|MSH6_HUMAN DNA mismatch repair protein Msh6 (Gene Name=MSH6)

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