Structure of PDB 2o4i Chain B Binding Site BS01

Receptor Information
>2o4i Chain B (length=218) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPVP
RPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILL
RAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAA
LKALEQARKSYSLGSIYTRLYWQAPTDSATAEGDVLTLLSICQWKPQALL
QWVDEHARPFSTVKPMYG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2o4i Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		D18 L19 E20 A21 L24 A81 N125 Y129 S176 S178 L179
Binding residue
(residue number reindexed from 1)		D10 L11 E12 A13 L16 A73 N117 Y121 S160 S162 L163
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2o4i, PDBe:2o4i, PDBj:2o4i
PDBsum2o4i
PubMed17355961
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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