Structure of PDB 2nup Chain B Binding Site BS01

Receptor Information
>2nup Chain B (length=731) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGLRVVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQ
TQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVSFL
DQRRWKCNLCYRVNDVPEEFLEPHRRPEVQNATIEFMAPSEYMLRPPQPP
VYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIH
FYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKELVQDLLKTLPQ
MFTKTLETQSALGPALQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREE
PNHRSSAKMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISR
YSAGSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGL
SIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSAL
LYTSSKGERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMT
ASLSDARDALVNAVIDSLSAYRSSVPGLMVPFSLRLFPLFVLALLKQKSF
QTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISD
RTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQ
NYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMK
ANFLQNMIEDRTESALSYYEFLLHIQQQVNK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2nup Chain B Residue 1100 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2nup The Transport Signal on Sec22 for Packaging into COPII-Coated Vesicles is a Conformational Epitope
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C431 C434 C452 C455
Binding residue
(residue number reindexed from 1)		C86 C89 C107 C110
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Cellular Component
GO:0030127 COPII vesicle coat

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2nup, PDBe:2nup, PDBj:2nup
PDBsum2nup
PubMed17499046
UniProtO95486|SC24A_HUMAN Protein transport protein Sec24A (Gene Name=SEC24A)

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