Structure of PDB 2mp0 Chain B Binding Site BS01

Receptor Information
>2mp0 Chain B (length=149) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIG
KIFETNHAFSIESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDT
VIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVGETPVIRIK
Ligand information
Ligand IDPO3
InChIInChI=1S/O3P/c1-4(2)3/q-3
InChIKeyAQSJGOWTSHOLKH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P-]([O-])=O
ACDLabs 10.04[O-][PH2-]([O-])=O
OpenEye OEToolkits 1.5.0[O-][P-](=O)[O-]
FormulaO3 P
NamePHOSPHITE ION
ChEMBL
DrugBank
ZINC
PDB chain2mp0 Chain B Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2mp0 Visualizing an ultra-weak protein-protein interaction in phosphorylation signaling.
ResolutionN/A
Binding residue
(original residue number in PDB)		F371 H375
Binding residue
(residue number reindexed from 1)		F53 H57
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) T373 H375 H390
Catalytic site (residue number reindexed from 1) T55 H57 H72
Enzyme Commision number 2.7.1.-
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0016310 phosphorylation
GO:0034763 negative regulation of transmembrane transport
GO:0043610 regulation of carbohydrate utilization
GO:0045912 negative regulation of carbohydrate metabolic process
GO:1902344 negative regulation of maltose transport
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:1902495 transmembrane transporter complex
GO:1990154 enzyme IIA-maltose transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2mp0, PDBe:2mp0, PDBj:2mp0
PDBsum2mp0
PubMed25131700
UniProtP69783|PTGA_ECOLI PTS system glucose-specific EIIA component (Gene Name=crr)

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