Structure of PDB 2iy5 Chain B Binding Site BS01

Receptor Information
>2iy5 Chain B (length=780) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRVPFSWLKAYVPELESPEVLEERLAGLGFETDRIERVFPIPRGVVFARV
LEAHPIPGTRLKRLVLDAGRTVEVVSGAENARKGIGVALALPGTELPGLG
QKVGERVIQGVRSFGMALSPRELGVGEYGGGLLEFPEDALPPGTPLSEAW
PEEVVLDLEVTPNRPDALGLLGLARDLHALGYALVEPEAALKAEALPLPF
ALKVEDPEGAPHFTLGYAFGLRVAPSPLWMQRALFAAGMRPINNVVDVTN
YVMLERAQPMHAFDLRFVGEGIAVRRAREGERLKTLDGVERTLHPEDLVI
AGWRGEESFPLGLAGVMGGAESEVREDTEAIALEVACFDPVSIRKTARRH
GLRTEASHRFERGVDPLGQVPAQRRALSLLQALAGARVAEALLEAGSPKP
PEAIPFRPEYANRLLGTSYPEAEQIAILKRLGCRVEGEGPTYRVTPPSHR
LDLRLEEDLVEEVARIEGYETIPLALPAFFPAPDNRAVEAPYRKEQRLRE
VLSGLGFQEVYTYSFMDPEDARRFRLDPPRLLLLNPLAPEKAALRTHLFP
GLVRVLKENLDLDRPERALLFEVGRVFREREETHLAGLLFGEGVGLPWAK
ERLSGYFLLKGYLEALFARLGLAFRVEAEAFPFLHPGVSGRVLVEGEEVG
FLGALHPEIAQELELPPVHLFELRLPLPDKPLAFQDPSRHPAAFRDLAVV
VPAPTPYGEVEALVREAAGPYLESLALFDLYQGPPLPEGHKSLAFHLRFR
HPKRTLRDEEVEEAVSRVAEALRARGFGLR
Ligand information
>2iy5 Chain T (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gccgagguagcucaguugguagagcaugcgacugaaaaucgcaguguccg
cgguucgauuccgcgccucggcacca
.<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<
<<<.......>>>>>>>>>>>.....
Receptor-Ligand Complex Structure
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PDB2iy5 The crystal structure of the ternary complex of phenylalanyl-tRNA synthetase with tRNAPhe and a phenylalanyl-adenylate analogue reveals a conformational switch of the CCA end.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R689 P691 A693 F694 R695 D696 Y731 P735 R757 D758 L779 R780
Binding residue
(residue number reindexed from 1)		R689 P691 A693 F694 R695 D696 Y731 P735 R757 D758 L779 R780
Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0009328 phenylalanine-tRNA ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2iy5, PDBe:2iy5, PDBj:2iy5
PDBsum2iy5
PubMed16939209
UniProtQ5SGX1|SYFB_THET8 Phenylalanine--tRNA ligase beta subunit (Gene Name=pheT)

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