Structure of PDB 2ihm Chain B Binding Site BS01

Receptor Information
>2ihm Chain B (length=336) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMPAYACQRPSPLTHHNTLLSEALETLAEAAGFEANEGRLLSFSRAASVL
KSLPCPVASLSQLHGLPYFGEHSTRVIQELLEHGTCEEVKQVRCSERYQT
MKLFTQVFGVGVKTANRWYQEGLRTLDELREQPQRLTQQQKAGLQYYQDL
STPVRRADAEALQQLIEAAVRQTLPGATVTLTGGFRRGKLQGHDVDFLIT
HPEEGQEVGLLPKVMSCLQSQGLVLYHQYFERSFCILGLPQPQQAGALPP
CPTWKAVRVDLVVTPSSQFPFALLGWTGSQFFERELRRFSRQEKGLWLNS
HGLFDPEQKRVFHATSEEDVFRLLGLKYLPPEQRNA
Ligand information
Receptor-Ligand Complex Structure
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PDB2ihm Structural insight into the substrate specificity of DNA Polymerase mu.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		L177 Q364 F387 E388 R389 R444 R447 R451 L458 N459
Binding residue
(residue number reindexed from 1)		L41 Q228 F230 E231 R232 R284 R287 R291 L298 N299
Enzymatic activity
Catalytic site (original residue number in PDB) D330 D332
Catalytic site (residue number reindexed from 1) D194 D196
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ihm, PDBe:2ihm, PDBj:2ihm
PDBsum2ihm
PubMed17159995
UniProtQ9JIW4|DPOLM_MOUSE DNA-directed DNA/RNA polymerase mu (Gene Name=Polm)

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