Structure of PDB 2igi Chain B Binding Site BS01

Receptor Information

>2igi Chain B (length=179) Species: 83333 (Escherichia coli K-12)

ANENNLIWIDLEMTGLDPERDRIIEIATLVTDANLNILAEGPTIAVHQSD
EQLALMDDWNVRTHTASGLVERVKASTMGDREAELATLEFLKQWVPAGKS
PICGNSIGQDRRFLFKYMPELEAYFHYRYLDVSTLKELARRWKPEILDGF
TKQGTHQAMDDIRESVAELAYYREHFIKL

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 2igi Chain B Residue 1007

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2igi Crystal Structure of Oligoribonuclease, the lone essential exoribonuclease in Escherichia coli
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): D11 E13 D162
• Binding residue (residue number reindexed from 1): D10 E12 D161
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.15.-

Gene Ontology

Molecular Function

• GO:0000175 3'-5'-RNA exonuclease activity
• GO:0003676 nucleic acid binding
• GO:0004527 exonuclease activity
• GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
• GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters
• GO:0034611 oligoribonucleotidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006401 RNA catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:2igi, PDBe:2igi, PDBj:2igi
• PDBsum: 2igi
• UniProt: P0A784|ORN_ECOLI Oligoribonuclease (Gene Name=orn)