Structure of PDB 2i91 Chain B Binding Site BS01

Receptor Information
>2i91 Chain B (length=526) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDQTQPLNEKQVPNSEGCYVWQVSDMNRLRRFLCFGSEGGTYYIEEKKLG
QENAEALLRLIEDGKGCEVVQEIKTFSQEGRAAKQEPTLFALAVCSQCSD
IKTKQAAFRAVPEVCRIPTHLFTFIQFKKDLKWGRALRKAVSDWYNTKDA
LNLAMAVTKYKQRNGWSHKDLLRLSHIKPANEGLTMVAKYVSKGWKEVQE
AYKEKELSPETEKVLKYLEATERVKRTKDELEIIHLIDEYRLVREHLLTI
HLKSKEIWKSLLQDMPLTALLRNLGKMTADSVLAPASSEVSSVCERLTNE
KLLKKARIHPFHILVALETYKKGHGNRGKLRWIPDTSIVEALDNAFYKSF
KLVEPTGKRFLLAIDVSASMNQRVLGSILNASVVAAAMCMLVARTEKDSH
MVAFSDEMLPCPITVNMLLHEVVEKMSDITMGSTDCALPMLWAQKTNTAA
DIFIVFTDCETNVEDVHPATALKQYREKMGIPAKLIVCAMTSNGFSIADP
DDRGMLDICGFDSGALDVIRNFTLDL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2i91 Structural and biochemical basis for misfolded RNA recognition by the Ro autoantigen.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		Q173 R174 K236 R237 L259 T260
Binding residue
(residue number reindexed from 1)		Q162 R163 K225 R226 L248 T249
Binding affinityPDBbind-CN: Kd=26nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0034336 misfolded RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0030030 cell projection organization
Cellular Component
GO:0005737 cytoplasm
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2i91, PDBe:2i91, PDBj:2i91
PDBsum2i91
PubMed17041599
UniProtP42700|RO60_XENLA RNA-binding protein RO60 (Gene Name=ro60)

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