Structure of PDB 2i54 Chain B Binding Site BS01

Receptor Information
>2i54 Chain B (length=242) Species: 5665 (Leishmania mexicana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KAILLFDVDGTLTPPRNPETHDMKEALLKARAAGFKLGVVGGSDFAKQKE
QLGESILEDFDYVFSENGLLAYKDGKEFHRNSLLRALGNEKVVAFVKKCL
HLIADLDIPVQRGTFVEFRNGMFNVSPIGRNCSQQERDEFENLDKERHIR
EKLIRELKEAFPDYQLAYSVGGQISFDVFPKGWDKTYCLQFVENDFETIH
FFGDKTSEGGNDYEIFTDSRTIGHSVKTYKDTIAILEALLED
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2i54 Chain B Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2i54 Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms
Resolution2.1 Å
Binding residue
(original residue number in PDB)		D10 D12 D207
Binding residue
(residue number reindexed from 1)		D7 D9 D204
Annotation score1
Enzymatic activity
Enzyme Commision number 5.4.2.8: phosphomannomutase.
Gene Ontology
Molecular Function
GO:0004615 phosphomannomutase activity
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006013 mannose metabolic process
GO:0006487 protein N-linked glycosylation
GO:0009298 GDP-mannose biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2i54, PDBe:2i54, PDBj:2i54
PDBsum2i54
PubMed16963079
UniProtQ95ZD7

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