Structure of PDB 2i3w Chain B Binding Site BS01

Receptor Information

>2i3w Chain B (length=258) Species: 10116 (Rattus norvegicus)

KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDCKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNK
WWYDKGEC

Ligand information

• Ligand ID: GLU
• InChI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• InChIKey: WHUUTDBJXJRKMK-VKHMYHEASA-N
• SMILES:
  ACDLabs 12.01: O=C(O)C(N)CCC(=O)O
  OpenEye OEToolkits 1.7.0: C(CC(=O)O)C(C(=O)O)N
  OpenEye OEToolkits 1.7.0: C(CC(=O)O)[C@@H](C(=O)O)N
  CACTVS 3.370: N[C@@H](CCC(O)=O)C(O)=O
  CACTVS 3.370: N[CH](CCC(O)=O)C(O)=O
• Formula: C5 H9 N O4
• Name: GLUTAMIC ACID
• ChEMBL: CHEMBL575060
• DrugBank: DB00142
• ZINC: ZINC000001482113
• PDB chain: 2i3w Chain B Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2i3w Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): Y61 T91 R96 L138 G141 S142 T143 E193
• Binding residue (residue number reindexed from 1): Y58 T88 R93 L135 G138 S139 T140 E190
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0015276 ligand-gated monoatomic ion channel activity

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:2i3w, PDBe:2i3w, PDBj:2i3w
• PDBsum: 2i3w
• PubMed: 17018279
• UniProt: P19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)